Season 1 Episode 2. Mark replies: "What does that mean?? I literally have no idea what that is supposed to mean." when Jez says "yeah, well, at least I don't fancy elves and pixies."
Season 1 Episode 5, Jez thinks "Shall I ask what he means?" when Superhans says "It's a Savage Garden, my friend, a Savage Garden."
Season 7, Episode 2, Mark says "What does that even mean?" when Jez says "We don't make money, money makes us." in answer Jez says "It means I'm gonna light up a fatty and crack open my brand new xbox."
Season 8, Episode 5, Jez says "What do you mean, famine?" when Mark talks about Chariman Mao and his regimes that caused widespread famine.
Season 9, Episode 5, Mark: That was fun! And does it mean...? April replies: I think it means something.
Season 9, Episode 6, Super Hans says "Be the Canary. Full fucking Delia". Mark says "I don't know what you mean!" Jez replies "You go, girl!"